Listar por autor 

Listar por autor "Sánchez Mejías, Elisabeth"  

Mostrando ítems 1-14 de 14

    • Artículo
      Icon

      Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus 

      Sánchez Varo, Raquel María; Trujillo Estrada, Laura Isabel; Sánchez Mejías, Elisabeth; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Jiménez Muñoz, Sebastián; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Springer, 2012)
      Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease ...
    • Artículo
      Icon

      Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model 

      Jiménez Muñoz, Sebastián; Torres Canalejo, Manuel; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Caballero, Cristina M.; Ruano Caballero, Diego; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology Inc., 2011)
      Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
    • Artículo
      Icon

      Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus 

      Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
      Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
    • Artículo
      Icon

      Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients 

      Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; García León, Juan Antonio; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019)
      Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ...
    • Artículo
      Icon

      Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease 

      Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017)
      Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...
    • Artículo
      Icon

      Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

      García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
      Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s ...
    • Artículo
      Icon

      In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology 

      Trujillo Estrada, Laura Isabel; Jiménez Muñoz, Sebastián; Castro, Vanessa de; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (BioMed Central, 2013)
      Background: Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) ...
    • Ponencia
      Icon

      Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer 

      Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (2013)
      El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).
    • Artículo
      Icon

      Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative 

      Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)
      Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
    • Artículo
      Icon

      Monocyte-derived Cells Invade Brain Parenchyma and Amyloid Plaques in Human Alzheimer’s Disease Hippocampus 

      Muñoz-Castro, Clara; Mejías Ortega, Marina; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Trujillo Estrada, Laura; Jiménez, Sebastián; García León, Juan Antonio; Fernández Valenzuela, Juan José; Sánchez Mico, María Virtudes; Romero Molina, Carmen; Moreno González, Inés; Baglietto Vargas, David; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer Nature, 2023)
      Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the ...
    • Artículo
      Icon

      Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease 

      Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley, 2018)
      Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate ...
    • Artículo
      Icon

      Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis 

      Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Fernández Valenzuela, Juan José; Castro, Vanessa de; Mejías Ortega, Marina; Gómez Arboledas, Ángela; Jiménez, Sebastián; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Frontiers Media, 2021)
      Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that ...
    • Artículo
      Icon

      Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration 

      Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Sánchez Mico, María; Sánchez Varo, Raquel María; Núñez Díaz, Cristina; Trujillo Estrada, Laura Isabel; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)
      The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
    • Artículo
      Icon

      Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis 

      Sánchez Varo, Raquel María; Mejías Ortega, Marina; Fernández Valenzuela, Juan José; Núñez Díaz, Cristina; Cáceres Palomo, Laura; Vegas Gómez, Laura; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; García León, Juan Antonio; Moreno González, Inés; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Baglietto Vargas, David; Gutiérrez Pérez, Antonia (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
      Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease ...